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Figure 3 | Retrovirology

Figure 3

From: Kinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses

Figure 3

Effect of dNTP concentration on DNA-dependent DNA polymerization activity for lentiviral RT proteins. The primer extension reactions were conducted with the RT enzymes described except (A) 40-mer DNA template encoding the same sequence as the RNA template used in FigureĀ 1 and (B) 48-mer DNA template encoding conserved HIV-1 PBS under the same reaction condition described in FigureĀ 1. (C) Scheme explaining potential mechanistic ties between K m values of RT enzymes from lentiviruses encoding or non-encoding Vpx and cellular dNTP pools modulated by SAMHD1 and Vpx in macrophages.

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