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Table 2 Inhibitory potential of a variety of HIV-1 inhibitors towards WT and mutant virus strains containing one N -glycan deletion in gp41

From: The role of N-glycans of HIV-1 gp41 in virus infectivity and susceptibility to the suppressive effects of carbohydrate-binding agents

 

HHA (nM)

UDA (nM)

AH (nM)

2G12 (nM)

PRM-S ( μM)

T-20 (nM)

AMD3100 (nM)

WT

0.9 ± 0.2

25 ± 3

5.2 ± 1.0

1.1 ± 0.2

4.8 ± 0.4

340 ± 141

3.5 ± 0.6

N611Q

1.6 ± 0.3

32 ± 6

5.4 ± 0.2

0.9 ± 0.2

5.3 ± 0.1

247 ± 177

2.5 ± 0.7

N625Q

1.4 ± 0.3

27 ± 5

8.1 ± 1.2

1.3 ± 0.2

4.5 ± 0.8

702 ± 255

2.9 ± 1.1

N637Q

3.7 ± 1.4

57 ± 24

15 ± 8

3.0 ± 2.0

5.3 ± 0.4

664 ± 454

7.6 ± 5.0

N674Q

1.3 ± 0.4

32 ± 11

8.3 ± 0.8

1.9 ± 0.5

5.2 ± 0.2

1530 ± 1201

3.8 ± 1.5

  1. Values represent the EC50’s (50% effective concentration) of the test compounds expressed in nM or μM.
  2. Data are the means ± SEM of at least 2 to 3 independent experiments.