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Table 2 Inhibitory potential of a variety of HIV-1 inhibitors towards WT and mutant virus strains containing one N -glycan deletion in gp41

From: The role of N-glycans of HIV-1 gp41 in virus infectivity and susceptibility to the suppressive effects of carbohydrate-binding agents

  HHA (nM) UDA (nM) AH (nM) 2G12 (nM) PRM-S ( μM) T-20 (nM) AMD3100 (nM)
WT 0.9 ± 0.2 25 ± 3 5.2 ± 1.0 1.1 ± 0.2 4.8 ± 0.4 340 ± 141 3.5 ± 0.6
N611Q 1.6 ± 0.3 32 ± 6 5.4 ± 0.2 0.9 ± 0.2 5.3 ± 0.1 247 ± 177 2.5 ± 0.7
N625Q 1.4 ± 0.3 27 ± 5 8.1 ± 1.2 1.3 ± 0.2 4.5 ± 0.8 702 ± 255 2.9 ± 1.1
N637Q 3.7 ± 1.4 57 ± 24 15 ± 8 3.0 ± 2.0 5.3 ± 0.4 664 ± 454 7.6 ± 5.0
N674Q 1.3 ± 0.4 32 ± 11 8.3 ± 0.8 1.9 ± 0.5 5.2 ± 0.2 1530 ± 1201 3.8 ± 1.5
  1. Values represent the EC50’s (50% effective concentration) of the test compounds expressed in nM or μM.
  2. Data are the means ± SEM of at least 2 to 3 independent experiments.