Figure 8
Conservation of N -linked glycosylation sites in gp41 of several HIV subtypes. An alignment of consensus sequences (2004) was obtained from the HIV sequence database [23] and was analysed using the program N-glycosite [23] to predict N-linked glycosylation sites in gp41. The alignment contained consensus sequences for HIV subtypes A1, A2, B, C, D, F1, F2, G, H, CRF01-AE, CRF02-AG, CRF03-AB, CRF04-cpx, CRF06-cpx, CRF08-BC, CRF10-CD, CRF11-cpx, CRF12-BF, and CRF14-BG. The consensus of consensus sequences and the ancestral sequences were excluded from the analysis. The fraction of HIV subtypes containing a glycosylation site at a specific location was determined. The positions (HXB2 numbering) of the glycosylated asparines are incidated on top of the lines. Glycosylation sites that were absent in HIV-1NL4.3 are indicated between parentheses.