Figure 5
From: Preexisting compensatory amino acids compromise fitness costs of a HIV-1 T cell escape mutation
The prevalence of the T cell escape mutations in T cell epitopes with or without compensatory amino acids. One sequence from each HIV-1 infected individual in the Los Alamos HIV-1 Sequence Database was analyzed for four well-studied T cell epitopes (TW10, TL9, KR11 and ISW9). Over 4000 sequences were analyzed for each epitope. The frequency of the sequences with the CTL escape mutations and the frequency of the CTL mutant sequences with and without the compensatory amino acids were determined for each CTL epitope.