Figure 3From: The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integraseSPR analysis of BI-D interactions with WT and H171T mutant IN CCDs. SPR binding kinetics for BI-D interactions with (A) WT IN CCD and (B) H171T IN CCD at indicated inhibitor concentrations. Binding affinities are summarized in C.Back to article page