Skip to main content
Figure 1 | Retrovirology

Figure 1

From: Differences in coreceptor specificity contribute to alternative tropism of HIV-1 subtype C for CD4+T-cell subsets, including stem cell memory T-cells

Figure 1

Proportion of CD4+T-cell subsets infected by Env-pseudotyped GFP reporter viruses. (a) Values represent the percentage of infected CD4+ T-cells that belong to the indicated subset; naïve (TN, dark blue), stem cell memory (TSCM, red), central memory (TCM, yellow), transitional memory (TTM, light blue), effector memory (TEM, purple) and effector memory RA (TEMRA, green). Values were averaged across four HIV-seronegative donors. Error bars represent the standard deviation. CD4+ T-cells were infected with GFP reporter viruses pseudotyped with (i) subtype C HIV-1 Envs isolated from plasma samples of subjects 1503, 1854 and 1109 provided at enrolment (E), 1-year later (I; intermediate) and 3-years after enrolment (F; final), or (ii) subtype B HIV-1 control Envs. Text in parentheses indicates the number of Envs isolated per plasma sample and/or Env coreceptor usage; CCR5-specific (R5), CXCR4-specific (X4), uses CCR5 or CXCR4 (R5X4). (b) Values represent the percentage of infected CD4+ T-cells that are TSCM for each Env-pseudotyped GFP reporter virus per donor (individual dots). Columns display the mean and standard deviation. Statistical analyses were performed using Mann Whitney tests, p-values ≤0.05 were considered significant.

Back to article page