Skip to main content

Advertisement

Table 1 Effects of MxB restriction on HIV-1 integration site preferences a

From: Host and viral determinants for MxB restriction of HIV-1 infection

Library Unique sites Within Refseq genes (%) Within 5 kb (+/- 2.5 kb) of TSS (%) Within 5 kb (+/- 2.5 kb) of CpG island (%) Average gene density within 1 Mb (+/- 0.5 Mb) of integration sitesb
HOS cells 476 305 302 900 (63.6)c 14 814 (3.11)d 13 737 (2.88)e 19.3
HOS-MxB cells 50 065 29 041 (58.0)f 1 126 (2.25)g 986 (1.97)h 14.0
MRC 476 280 171 999 (36.1) 15 334 (3.22) 13 101 (2.75) 8.8
  1. aStatistical comparisons performed by Fisher’s exact test.
  2. bBased on complete genes. See Figure 6C for statistical analysis.
  3. cP value versus MRC, <2.2 × 10-308; versus HOS-MxB cells, 4.4 × 10-132.
  4. dP value versus MRC, 0.002; versus HOS-MxB cells, 2.6 × 10-35.
  5. eP value versus MRC, 8.4 × 10-5; versus HOS-MxB cells, 3.5 × 10-35.
  6. fP value versus MRC, <2.2 × 10-308.
  7. gP value versus MRC, 2.6 × 10-35.
  8. hP value versus MRC, 7.4 × 10-27.