Skip to main content

Table 1 Effects of MxB restriction on HIV-1 integration site preferences a

From: Host and viral determinants for MxB restriction of HIV-1 infection

Library

Unique sites

Within Refseq genes (%)

Within 5 kb (+/- 2.5 kb) of TSS (%)

Within 5 kb (+/- 2.5 kb) of CpG island (%)

Average gene density within 1 Mb (+/- 0.5 Mb) of integration sitesb

HOS cells

476 305

302 900 (63.6)c

14 814 (3.11)d

13 737 (2.88)e

19.3

HOS-MxB cells

50 065

29 041 (58.0)f

1 126 (2.25)g

986 (1.97)h

14.0

MRC

476 280

171 999 (36.1)

15 334 (3.22)

13 101 (2.75)

8.8

  1. aStatistical comparisons performed by Fisher’s exact test.
  2. bBased on complete genes. See Figure 6C for statistical analysis.
  3. cP value versus MRC, <2.2 × 10-308; versus HOS-MxB cells, 4.4 × 10-132.
  4. dP value versus MRC, 0.002; versus HOS-MxB cells, 2.6 × 10-35.
  5. eP value versus MRC, 8.4 × 10-5; versus HOS-MxB cells, 3.5 × 10-35.
  6. fP value versus MRC, <2.2 × 10-308.
  7. gP value versus MRC, 2.6 × 10-35.
  8. hP value versus MRC, 7.4 × 10-27.
Back to article page

Retrovirology

ISSN: 1742-4690

Contact us