Resistance pathway | Construct | Infectivity | Â | Kinetics | Â | N44 resistance | |
---|---|---|---|---|---|---|---|
Relative infectivitya,b | SEM (+/−) | T1/2 (min)c | SEM (+/−) | Relative N44 resistancea,b | SEM (+/−) | ||
WT | WT-WT | 1.00 | 0.28 | 53.13 | 0.61 | 1.04 | 0.14 |
 | C1-WT | 1.77 | 0.11 | 61.83 | 0.80 | 1.09 | 0.07 |
 | C2-WT | 1.69 | 0.08 | 61.39 | 2.10 | 1.20 | 0.13 |
 | C3-WT | 1.07 | 0.10 | 59.00 | 1.26 | 1.10 | 0.05 |
 | C4-WT | 2.21 | 0.11 | 58.91 | 1.17 | 1.23 | 0.03 |
 | WT-V833Id | 1.28 | 0.44 | 56.48 | 1.80 | 1.04 | 0.08 |
 | WT-P714Ld | 1.54 | 0.14 | 56.68 | 3.77 | 1.09 | 0.12 |
E560K | WT-E560K | 0.40 | 0.04 | 58.06 | 1.59 | 1.29 | 0.09 |
 | WT-C1 | 0.18 | 0.07 | 64.98 | 0.80 | 2.50 | 0.03 |
 | C1-C1 | 0.51 | 0.15 | 71.13 | 0.64 | 2.37 | 0.03 |
 | C4-C1 | 0.22 | 0.08 | 69.36 | 0.72 | 2.34 | 0.19 |
 | WT-C2 | 0.73 | 0.20 | 66.98 | 2.50 | 2.26 | 0.30 |
 | C2-C2 | 0.39 | 0.01 | 72.00 | 0.41 | 1.58 | 0.05 |
 | C3-C2 | 0.83 | 0.30 | 66.69 | 3.12 | 2.14 | 0.07 |
 | WT-C6 | 0.43 | 0.06 | 67.36 | 1.90 | 3.40 | 0.11 |
 | C6-C6 | 0.38 | 0.00 | 65.54 | 2.19 | 3.22 | 0.11 |
Dual | C2-KKR | 0.53 | 0.16 | 68.54 | 2.28 | 1.61 | 0.23 |
 | C4-KKR | 0.29 | 0.04 | 67.66 | 0.85 | 1.87 | 0.28 |
 | WT-KKR | 0.60 | 0.26 | 64.92 | 1.50 | 2.10 | 0.03 |
E648K | WT-C3 | 1.40 | 0.14 | 48.82 | 0.60 | 1.88 | 0.02 |
 | C3-C3 | 1.23 | 0.36 | 54.41 | 1.85 | 1.84 | 0.21 |
 | C2-C3 | 1.75 | 0.05 | 64.62 | 3.90 | 1.50 | 0.03 |
 | WT-C4 | 2.35 | 0.65 | 52.92 | 1.35 | 3.59 | 0.16 |
 | C4-C4 | 1.27 | 0.29 | 58.06 | 1.34 | 3.86 | 0.30 |
 | C1-C4 | 0.81 | 0.20 | 65.18 | 1.76 | 2.52 | 0.04 |
 | C4-C4-Te | 1.23 | 0.39 | 61.33 | 1.91 | 3.39 | 0.42 |
 | C5-C5 | 0.15 | 0.05 | 69.73 | 4.70 | 0.96 | 0.06 |
 | C5-C5-Te | 0.26 | 0.06 | 70.28 | 2.30 | 0.90 | 0nnn12 |