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Figure 3 | Retrovirology

Figure 3

From: Resistance to N-peptide fusion inhibitors correlates with thermodynamic stability of the gp41 six-helix bundle but not HIV entry kinetics

Figure 3

Pseudoviruses with Envs from resistance cultures have slower entry kinetics than WT. (A) Entry of β-Lactamase-Vpr pseudoviruses inoculated onto HeLa cells with high CD4 and high CCR5 receptor levels (JC53), normalized to the fusion plateau. Each time point is the average of at least three separate pseudovirus lots tested in independent experiments (±S.E.M). (B-C) The time to half maximal (T1/2) fusion in target cells comparing (B) parental resistant Envs to WT, or (C) Env containing only gp41mutations to WT. *unpaired t-test indicates P values <0.05.

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