Figure 2
From: Reduced evolutionary rates in HIV-1 reveal extensive latency periods among replicating lineages
The false discovery rate (FDR) of our phylogenetic latency detection method. Because our latency detection method performs many tests, the risk of false positives increases. This figure shows the FDR as a function of the total number of positives detected (TP + FP). The FDR depended strongly on the number of latency periods (panels), and on the number of taxa compared (lines); cyan = 10 taxa, green = 20 taxa, blue = 30 taxa, purple = 40 taxa, magenta = 50 taxa, and red = 60 taxa. Each line shows the mean of 50,000 simulated random phylogenies at flatent = 0.5–0.9. Means were calculated when ≥50 observations occurred at any TP + FP level. The hairline shows FDR = 0.05.