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Table 3 Correlation between antibody function and DLS results in post-vaccination serum

From: Aggregate complexes of HIV-1 induced by multimeric antibodies

Summary of correlations between outcomes of antibody function assays and aggregation
Immunoglobulin activity assay Correlation to v8 Size (nm) n: Donors with correlated data
Viral strain/Epitope Assay type Isotype Pearson R Adj. P value
ConS gp140 Antigen binding IgA -0.538 0.014 20
NL4-3 Virus capture IgG -0.486 0.022 22
A244 gp120 gD- Antigen binding IgA -0.461 0.041 20
gp120 C5 domain Epitope mapping IgG 0.591 0.056 11
A244 Virus capture IgG -0.441 0.067 18
TH023 Neutralization Mixed -0.261 0.171 29
MN gp120 Antigen binding IgA -0.308 0.186 20
gp120 C1 domain Epitope mapping IgG 0.373 0.259 11
MN Virus capture IgG -0.205 0.372 21
MN Virus capture IgA 0.169 0.398 27
A244 gp120 gD+ Antigen binding IgA -0.153 0.519 20
MN Neutralization Mixed -0.116 0.548 29
gp120 V3 domain Epitope mapping IgG 0.182 0.593 11
A244 gD+ ADCC IgG 0.080 0.684 28
gp120 V2 domain Epitope mapping IgG 0.127 0.709 11
WITO Virus capture IgG 0.086 0.735 18
WITO Virus capture IgA -0.077 0.742 21
NL4-3 Virus capture IgA -0.059 0.772 27
CM243 ADCC IgG -0.027 0.891 29
Multiple strains Binding breadth IgA -0.022 0.911 29
  1. Results for ADCC, neutralization and IgG Virion capture have been previously reported [27],[29],[32].