Table 2 Comparison of various mechanisms of lentiviral Vif-mediated degradation of A3 proteins
Lentivirus | E3 complex | Method of binding with EloC | Cul2/Cul5 | Method of binding with Cul | CBF-βinvolved |
|---|---|---|---|---|---|
HIV | Y | BC box (SLQ) | Cul5 | zinc finger | Y |
SIV | Y | BC box (SLQ) | Cul5 | zinc finger | Y |
FIV | Y | BC box (TLQ) | Cul5 | unknown | N |
BIV | Y | BC box (SLQ) | Cul2 | zinc binding loop | N |
MVV | Y | BC box (SLQ) | Cul5 | unknown | N |