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Figure 6 | Retrovirology

Figure 6

From: Partial rescue of V1V2 mutant infectivity by HIV-1 cell-cell transmission supports the domain’s exceptional capacity for sequence variation

Figure 6

Point mutations in V1V2 reduce free virus infectivity stronger than cell-cell transmission capacity. A panel of JR-CSF V1V2 point mutations was compared for entry efficacy in free virus infection (black) and cell-cell transmission (red). Env mutant infectivities were normalized to JR-CSF wt and are ranked (left to right) in order of increasing free virus infectivity. Values of relative efficacy of each mutant in cell-cell transmission over free virus infection are indicated below the bars; stars depict whether this difference reached statistical significance as probed by multiple unpaired t-tests with alpha = 0.05. Data shown are means and SD from 3 independent experiments performed in duplicates.

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Retrovirology

ISSN: 1742-4690

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