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Table 5 The network of correlated mutations in compartmentalization hot spot positions across HIV-1 env

From: Single genome analysis reveals genetic characteristics of Neuroadaptation across HIV-1 envelope

aa1

aa2

Patients

225 (C2 29)

300 (V3 5)

NCN4, ANI1

290 (C2 94)

389 (V4 5)

NCN4, MND2

293 (C2 97)

337 (C3 6)

NCN4, ANI6

300 (V3 5)

535 (gp41 24)

NCN2, ANI1

300 (V3 5)

641 (gp41 130)

NCN2, ANI1

305 (V3 10)

362 (C3 31)

NCN4, NCN5

305 (V3 10)

724 (gp41 213)

NCN4, NCN5

336 (C3 5)

337 (C3 6)

NCN3, ANI2, MND1

337 (C3 6)

362 (C3 31)

NCN4, MND1

346 (C3 15)

620 (gp41 109)

ANI1, ANI7

362 (C3 31)

389 (V4 5)

ANI1, MND1, MND2

362 (C3 31)

392 (V4 8)

NCN5, ANI1

362 (C3 31)

724 (gp41 213)

NCN4, NCN5

389 (V4 5)

462 (V5 3)

ANI4, MND1, MND2

462 (V5 3)

463 (V5 4)

ANI2, MND1

535 (gp41 24)

641 (gp41 130)

NCN2, ANI1

  1. Compartmentalization Hot spots with amino acids sharing mutual information (MI) in ≥ 2 subjects, an MI value of ≥ 0.10 and a Benjamini–Hochberg adjusted p-value for the correlation < 0.05. HXB2 gp160 numbering for amino acids (aa1 and aa2) followed by corresponding gene-region specific amino acid positions are shown.