Single genome analysis reveals genetic characteristics of Neuroadaptation across HIV-1 envelope

Retrovirology

Table 1 Clinical and demographic profiles for study participants

Participant	NCN1	NCN2	NCN3	NCN4	NCN5	NCN6	ANI1	ANI2	ANI3	ANI4	ANI5	ANI6	ANI7	MND1	MND2
Age	52	41	42	41	45	43	61	51	42	44	37	34	62	40	32
Sex	M	M	M	M	M	M	M	M	M	M	M	M	M	M	F
Race/Ethnicity	White	Black	Black	White	Black	White	White	White	Black	White	Hispanic	White	White	Black	Black
Est. Dur. Inf	59.6	173.1	48.9	214.4	75.3	136.9	154.1	211.7	46.2	56.2	26.5	59.8	206.6	75.0	58.5
ARV Status	No ARVs	Naïve	No ARVs	Naïve	Naïve	No ARVs	Naïve	No ARVs	Naïve	Naïve	Naïve	No ARVs	No ARVs	Naïve	No ARVs
CD4 Count	591	802	687	790	420	418	743	220	819	237	244	329	466	398	320
CD4 Nadir	400	554	491	461	297	392	537	220	495	237	244	329	215	398	320
Plasma VL	65,600	749	8,620	13,900	19,700	18,900	5,320	29,800	1,890	38,600	9,210	13,000	50,100	6,250	44,900
CSF VL	120	120	6,600	14,700	18,300	2,910	3,210	5,930	129	1320	653	2430	4,330	454	2,690
RPR	Neg	Neg	Neg	Neg	Neg	Neg	Neg	Neg	Neg	Neg	Neg	Neg	Neg	Neg	Neg
HCV	Neg	Neg	Neg	Neg	Neg	Neg	Neg	Neg	Neg	Neg	Neg	Neg	Neg	Neg	Neg

Participant neurocognitive disease classifications are as follows: NCN = Normal neurocognitive performance; ANI = Asymptomatic neurocognitive impairment; MND = Mild neurocognitive disorder. M = male, F = female. Estimated Duration of Infection (Est. Dur. Inf) is shown in months. CD4+ T Cell Count (CD4 Count) is in cells/mm³, plasma and CSF HIV-1 RNA levels (VL) are in copies/mL. RPR = rapid plasma reagin. HCV = hepatitis C virus.

ISSN: 1742-4690