Figure 1

Identification of a conserved sequence for the detection of recently integrated HML-2 proviruses. A BLAT search of the 2009 human genome sequence build GRCh37/Hg19 for the ~32 bp K-seq sequence (shown in box) returned each provirus included in the alignment. The aligned sequences have been ordered with reference to percent identity to the K113 nucleotide sequence to depict the conservation of the region among the most recently formed germline integrations. Bases shared with K113 are indicated as dots, and differences are indicated by the base present at that site. Asterisks at left indicate A. human-specific and B. polymorphic proviruses; C. predicted fragment sizes (in bp) based on restriction analysis of the published human genome (Hg19); D. reference aliases of each provirus; E. chromosomal locus of each analyzed element.