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Figure 7 | Retrovirology

Figure 7

From: A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants

Figure 7

Models of analogues 7 (cyan) and 9 (magenta) bound to K103N/Y181C RT. (A) Overlay of the two compounds as modeled in the binding pocket of K103N/Y181C HIV-1 RT. (B) The exocyclic amine in 9 cannot H-bond with the backbone NH of K101, as seen in crystal structures of 1. The N3 and linker NH both bind a water molecule that forms a bridge to the backbone carbonyl of E138. (C) The H-bonds with the backbone of K101 are restored in 7. In addition, the exocyclic amine and linker NH both H-bond a water molecule in a different orientation than is seen with 9.

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Retrovirology

ISSN: 1742-4690

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