Figure 3

Activities and cytotoxicities of rilpivirine (1) and its analogues. EC_50s, as measured by reduction of luciferase reporter activity, are reported as nM values, CC_50s are reported as μM values. Standard deviations are indicated in parentheses. Shading of EC₅₀ values indicates a log scale: no shading = EC₅₀ <1.0 nM, light gray = EC₅₀ between 1.0 nM and 9.9 nM, dark gray = EC₅₀ between 10 nM and 99nM, black = EC₅₀ ≥100 nM. Therapeutic Index (T.I.) is the ratio of CC₅₀/EC₅₀.