Compound | EC50μM | CC50μM |
|---|
HIV-1 IIIB | NL4.3/WT | NL4.3/DS5000R | NL4.3/AMD3100R | AZTR | NNRTIRK103N:Y181C | HIV-2 ROD |
|---|
| | | | (165) | (>100) | (>30) | (>85) | | |
WDO-217 | 1.04 ± 0.2 | 0.9 ± 0.05 | 1.2 ± 0.1 | 1.7 ± 0.9 | 1.5 ± 0.6 | 1.3 ± 0.4 | 1.04 ± 0.3 | 75 ± 11 |
- GFP-assay in Jurkat cells.
- Values are presented as mean ± std dev from at least 3 independent experiments. Fold resistance of mutant strains towards the respective inhibitor of resistant strains is given in parenthesis (EC50 for NL4.3 wild-type as 1).
- EC
50
: 50% effective concentration, concentration of inhibitor required for 50% inhibition of viral replication.
- CC
50
: 50% cytotoxic concentration, concentration of inhibitor that kills 50% of the cells.
