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Table 1 Antiretroviral activity and cytotoxicity of WDO-217 in the MT-4/MTT-assay

From: A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions

Compound

EC50(μM)

CC50(μM)

HIV-1 IIIB

HIV-2 ROD

SIV Mac251

WDO-217

7.9 ± 3.3

2.3 ± 0.3

5.3 ± 1.5

72 ± 11

AZT

0.007 ± 0.001

0.005 ± 0.0008

0.016 ± 0.007

>35

  1. Values are presented as mean ± std dev from at least 3 independent experiments.
  2. EC 50 : 50% effective concentration, concentration of inhibitor required for 50% inhibition of viral replication.
  3. CC 50 : 50% cytotoxic concentration, concentration of inhibitor that kills 50% of the cells.