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Figure 7 | Retrovirology

Figure 7

From: CDK2 Regulates HIV-1 Transcription by Phosphorylation of CDK9 on Serine 90

Figure 7

Modeling of Ser90-containing loop. (A) Structure of Ser90-containing loop of CDK9 (model based on PDB 3MIA). Conformation of residues Thr87-Ser98 with the lowest energy. Backbone representation of residues present in original PDB structure is shown in blue color. Ser90 is emphasized by thickening. (B) Structure of CDK9/cyclin T1/Tat complex (model based on PDB 3MIA). Backbone representation of CDK9 residues present in original PDB structure is shown in blue color. CDK9 Ser90 is shown as balls and sticks, in red color. Cyclin T1 and Tat are shown in green and magenta colors respectively. Bullets in cyclin backbone represent missing residues Lys253-Ala260. (C) Structure of CDK9/cyclin T1/Tat complex (model based on PDB 3MIA). Backbone representation of CDK9 residues present in original PDB structure is shown in blue color. Cyclin T1 and Tat are shown in green and magenta colors respectively. CDK9 Ser90, CDK9 Val8 and cyclinT1 Gln142 are shown as balls and sticks, in red, cyan and yellow color, respectively. Minimal distance between heavy atoms of CDK9 Ser90 and CDK9 Val8 is 11.38 Å; minimal distance between CDK9 Ser90 and cyclin T1 Gln142 is 12.41 Å. Positions of Val 8 and Gln142 are indicated. Figures were prepared with ICM-Pro software package.

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