Skip to main content

Table 1 Protein subunits of CCAPs depleted in this study

From: Identification of novel CDK9 and Cyclin T1-associated protein complexes (CCAPs) whose siRNA depletion enhances HIV-1 Tat function

Protein depleted CCAP Name Other names Function of depleted protein Reference
FBXO11 FBXO11 F-box protein 11 UBR6;VIT1; FBX11; PRMT9; UG063H01 Phosphorylation-dependent ubiquitination, regulates p53 and BCL6 [29, 30]
CUL1 Cullin 1 -
SKP1 S-phase kinase-associated protein 1 OCP2; p19A; EMC19; SKP1A; OCP-II; TCEB1L
PPP1R10   protein phosphatase 1, regulatory subunit 10 FB19; CAT53; PNUTS; PP1R10 Targets protein phosphatase-1 (PP1) to the nucleus, in DNA damage response [31]
WDR82 PNUTS WD repeat domain 82 SWD2; MST107; WDR82A; MSTP107; PRO2730; TMEM113; PRO34047 Component of the mammalian SET1A /SET1B histone H3-Lys4-methyltransferase complexes [32]
TOX3 TOX high mobility group box family member 3 CAGF9; TNRC9 Unwinding of DNA, chromatin structure alteration and neuronal transcription [33]
TPR TPR Translocated promoter region (to activated MET oncogene)   Directly interacts with several components of nuclear pore complexes (NPCs). Nuclear export of mRNAs and some proteins. [34]
TTF2 TTF2 Transcription termination factor, RNA polymerase II HuF2 Critical role in altering protein-DNA interactions. Has dsDNA-dependent ATPase and RNAPII termination activity. Plays a role in pre-mRNA splicing. [35, 36]
WRNIP1 WRNIP1 Werner helicase interacting protein 1 WHIP; bA420G6.2; RP11-420G6.2 Interacts with the N-terminal portion of Werner protein containing the exonuclease domain and implicated in Werner’s syndrome. It may influence aging process. [3739]
  1. The proteins that were depleted using siRNA in this study are listed. The core complex these proteins exist in cells as presented in Figure 1 is included along with brief description of their cellular function.