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Figure 4 | Retrovirology

Figure 4

From: Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome

Figure 4

Comparison of the growth of viruses NIA and T/F across 4 passages and three replicates. The two axes show, on a log scale, the genomes/ml of the two viruses at the end of each growth period before passage multiplied by the dilution factor as shown in Eq. (2). The binomial sampling errors for each variant are indicated by the vertical and horizontal lines through each point. If the ratio of the average growth rates of the two viruses at each passage is a constant, the 4 points should lie on a straight line (see Methods), with the slope giving 1+s ij . The maximum likelihood fit to this model is shown by the solid lines. The additional assumption of constant exponential growth rate for each individual variant would mean that the points are equispaced along the best fit line (see Methods)—this assumption is clearly violated by the data.

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