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Table 1 Integration frequency of HIV in RefSeq genes

From: HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells

 

Cell line

# sites

% in RefSeq genes

HIV-fLuc

WT

1468

77.5 ***|ns|***

sites

HRP-2 KD

359

80.2 ***|ns|***

 

LEDGF/p75 KD

477

67.7 ***|***|ns

 

LEDGF/p75 KD HRP-2 KD

676

53.7 ***|***|***

 

LEDGF/p75 KD + HRP-2

445

77.5 ***|ns|***

MRC sites

WT

4404

39.7

(HIV-fLuc)

HRP-2 KD

1077

37.9

 

LEDGF/p75 KD

1431

40.3

 

LEDGF/p75 KD HRP-2 KD

2028

39.3

 

LEDGF/p75 KD + HRP-2

1335

40.2

  1. Abbreviations: MRC matched random control, ns non-significant (p ≥ 0.05). Asterisks represent p-values (*p < 0.05, **p < 0.01, ***p < 0.001) given after comparison with MRC|WT|LEDGF/p75 KD respectively. Significance was determined using a two-tailed Chi-square test. P-values were not corrected for multiple comparisons; alpha level is 0.003 after Bonferroni-correction (0.05/15).