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Figure 4 | Retrovirology

Figure 4

From: HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells

Figure 4

LEDGF/p75 and HRP-2 depletion shifts integration towards random. A pooled score was determined for HIV-1 integration near epigenetic marks associated with transcriptional repression or activation for each cell line and plotted in a bar diagram. The X-axis represents deviation from random with positive values indicating favored integration compared to MRC, negative values disfavored integration compared to MRC. The pooled score is the average of the different ROC values - 0.5 (to indicate the deviation from random) obtained with individual markers (not shown) in a 10 kb window. For HeLaP4, H3K9me2, H3K9me3, H3K27me3, and H4K20me3 were pooled as associated with ‘repression’; H2BK5me1, H3K4me1, H3K36me3, H4K20me1 were pooled as associated with ‘activation’. For CD4+ T-cells, H3K9me2, H3K9me3, H3K27me2, H3K27me3, H3K79me3 and H4K20me3 were pooled as associated with ‘repression’; H2BK5me1, H3K4me1, H3K4me2, H3K9me1, H3K27me1, H3K36me3, H4K20me1 were pooled as associated with ‘activation’.

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