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Table 4 Regression analysis to predict viral load and CD4 count in patients without evidence of TDR

From: Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients

  Model 1 Model 2
Factors log VL (95% CI) p-value log VL (95% CI) p-value
log10F PI 0.298 (0.122 – 0.421) 0.000 0.269 (0.105 – 0.433) 0.001
log10F RTI -0.090 (-0.324 – 0.144) 0.449 -0.219 (-0.583 – 0.144) 0.237
Factors sqrt CD4 (95% CI) p-value sqrt CD4 (95% CI) p-value
log10F PI -2.038 (-3.556 – -0.521) 0.009 -1.947 (-3.446 – -0.448) 0.011
log10F RTI 1.220 (-2.145 – 4.585) 0.477 1.243 (-2.074 – 4.560) 0.462
  1. Linear regression analyses of the association between genotypic predictors and clinical parameters. Patients that did show genotypic evidence of TDR were excluded from the analysis. For each of the genotypic predictors, two models including different sets of potential confounders were performed. Model 1 included genotypic predictors for PR and RT, and estimated duration of infection. Model 2 additionally included age, sex, risk group and area of origin.