| |
Model 1
|
Model 2
|
|---|
|
Factors
|
log VL (95% CI)
|
p-value
|
log VL (95% CI)
|
p-value
|
|---|
|
TDR
PI
|
-0.073 (-0.287 – 0.140)
|
0.500
|
-0.080 (-0.290 – 0.129)
|
0.451
|
|
TDR
RTI
|
-0.009 (-0.157 – 0.138)
|
0.903
|
-0.003 (-0.147 – 0.142)
|
0.971
|
|
log10F
PI
|
0.271 (0.122 – 0.420)
|
0.000
|
0.251 (0.104 – 0.398)
|
0.001
|
|
log10F
RTI
|
-0.090 (-0.324 – 0.144)
|
0.449
|
-0.133 (-0.363 – 0.097)
|
0.258
|
|
log10FPI−m
|
0.314 (0.156 – 0.472)
|
0.000
|
0.294 (0.137 – 0.450)
|
0.000
|
|
log10FRTI−m
|
-0.117 (-0.459 – 0.223)
|
0.498
|
-0.180 (-0.516 – 0.155)
|
0.292
|
|
Factors
|
sqrt CD4 (95% CI)
|
p-value
|
sqrt CD4 (95% CI)
|
p-value
|
|
TDR
PI
|
-0.357 (-2.313 – 1.600)
|
0.721
|
-0.501 (-2.417 – 1.416)
|
0.609
|
|
TDR
RTI
|
0.507 ( -0.844 – 1.859)
|
0.462
|
0.362 (-0.963 – 1.688)
|
0.592
|
|
log10F
PI
|
-1.628 (-2.999 – 0.257)
|
0.020
|
-1.540 (-2.891 – -0.189)
|
0.025
|
|
log10F
RTI
|
1.465 (-0.683 – 3.613)
|
0.181
|
1.583 (-0.527 – 3.692)
|
0.141
|
|
log10FPI−m
|
-1.861 (-3.314 – -0.407)
|
0.012
|
-1.779 (-3.213 – -0.346)
|
0.015
|
|
log10FRTI−m
|
1.400 (-1.733 – 4.532)
|
0.381
|
1.356 (-1.727 – 4.439)
|
0.389
|
- Linear regression analyses of the association between genotypic predictors and clinical parameters. Viral load values were log transformed and CD4 counts were square root transformed to approximate the normal distribution. For each of the genotypic predictors, two models including different sets of potential confounders were investigated. Model 1 included genotypic predictors for PR and RT, and estimated duration of infection (recent vs unknown duration). Model 2 additionally included age, gender, risk group and area of origin.
