HIV-1 subtype C superinfected individuals mount low autologous neutralizing antibody responses prior to intrasubtype superinfection

Table 1 Seroconverters from ZEHRP cohort evaluated for longitudinal autologous neutralization of initial variants

Subject ID	Linkage	Subtype	Last Seronegative Date	First Sample Date	Estimated days from infection^a	Viral load^b	Setpoint Viral load^c	Estimated timing of SI^d	Viral load at SI^e	Sex with Condom^f	Sex without Condom^f	Outside Partner^g	Initial Virus Env^h
ZM282M	Unlinked	C	8-Dec-04	3-Mar-05	43	>750,0000	253,000	10	300,0000	78	2	Yes	Founder
ZM211F	Unlinked	C	15-Mar-02	5-Jul-02	60	2640	14,454	9	14,454	11	3	No	Early
ZM247F	Unlinked	C	29-Jul-03	1-Nov-03	26	>750,000	67,472	3	43,428	112	26	No	Founder
ZM1072M	Unlinked	C	19-May-06	16-Aug-06	45	36,200	15,400	N/A	N/A	144	0	Yes	Founder
ZM297M	Unlinked	C	4-Mar-05	9-Jun-05	49	8,687	45,500	N/A	N/A	108	3	No	Early
ZM1464M	Unlinked	C	9-Dec-06	10-Mar-07	46	44,500	15,600	N/A	N/A	68	0	No	Early
ZM503F	Unlinked	C	2-Nov-06	9-Feb-07	50	25,800	17,100	N/A	N/A	65	0	No	Founder
ZM249M	Unlinked	C	6-May-03	12-Aug-03	29	>750,000	82,233	N/A	N/A	145	25	Yes	Founder
ZM267F	Unlinked	C	23-Mar-04	29-Jun-04	29	>750,000	50,061	N/A	N/A	188	8	No	Founder
ZM284M	Unlinked	C	14-Jan-05	9-Apr-05	22	>750,000	354,880	N/A	N/A	97	1	No	Early
ZM289M	Unlinked	C	30-Apr-05	19-May-05	41	399,737	4,512	N/A	N/A	75	8	No	Founder
ZM237M	Unlinked	C	29-Apr-03	29-Jul-03	46	44,870	59,250	N/A	N/A	41	4	No	Early
ZM184F	Unlinked	C	11-Apr-03	10-Jul-03	45	71,290	72,718	N/A	N/A	39	9	Yes	Early

Bolded subjects: superinfected individuals with evidence of superinfection from outsider partnerships or non-superinfected controls who self-reported outside partnerships.
^a Days from time of infection to first sample date was calculated, as follows: If only first Ab+ dates were available, time of infection was determined by the midpoint between last seronegative and first Ab+ date. If Ag+Ab- dates were available, time of infection was estimated by subtracting 22 days from Ag+Ab- dates. (Haaland 2009).
^b Viral load: RNA copies/ml in plasma at first sample date.
^c Viral load: RNA copies/ml in plasma at 7-12 months post-seroconversion.
^d Months post-seroconversion in which superinfection was detected, SI = Superinfection, N/A = Not Applicable.
^e Viral load: RNA copies/ml in plasma at time of superinfection detection.
^f Sexual data is cumulative events for 12 months (Kraft 2012).
^g Other partners self-reported for 12 months (Kraft 2012).
^h Denotes if initial virus envelope (Env) tested represents a transmitted/founder Env or an early founder-like Env isolated from first sample date.

ISSN: 1742-4690