Skip to main content

Table 1 Seroconverters from ZEHRP cohort evaluated for longitudinal autologous neutralization of initial variants

From: HIV-1 subtype C superinfected individuals mount low autologous neutralizing antibody responses prior to intrasubtype superinfection

Subject ID Linkage Subtype Last Seronegative Date First Sample Date Estimated days from infectiona Viral loadb Setpoint Viral loadc Estimated timing of SId Viral load at SIe Sex with Condomf Sex without Condomf Outside Partnerg Initial Virus Envh
ZM282M Unlinked C 8-Dec-04 3-Mar-05 43 >750,0000 253,000 10 300,0000 78 2 Yes Founder
ZM211F Unlinked C 15-Mar-02 5-Jul-02 60 2640 14,454 9 14,454 11 3 No Early
ZM247F Unlinked C 29-Jul-03 1-Nov-03 26 >750,000 67,472 3 43,428 112 26 No Founder
ZM1072M Unlinked C 19-May-06 16-Aug-06 45 36,200 15,400 N/A N/A 144 0 Yes Founder
ZM297M Unlinked C 4-Mar-05 9-Jun-05 49 8,687 45,500 N/A N/A 108 3 No Early
ZM1464M Unlinked C 9-Dec-06 10-Mar-07 46 44,500 15,600 N/A N/A 68 0 No Early
ZM503F Unlinked C 2-Nov-06 9-Feb-07 50 25,800 17,100 N/A N/A 65 0 No Founder
ZM249M Unlinked C 6-May-03 12-Aug-03 29 >750,000 82,233 N/A N/A 145 25 Yes Founder
ZM267F Unlinked C 23-Mar-04 29-Jun-04 29 >750,000 50,061 N/A N/A 188 8 No Founder
ZM284M Unlinked C 14-Jan-05 9-Apr-05 22 >750,000 354,880 N/A N/A 97 1 No Early
ZM289M Unlinked C 30-Apr-05 19-May-05 41 399,737 4,512 N/A N/A 75 8 No Founder
ZM237M Unlinked C 29-Apr-03 29-Jul-03 46 44,870 59,250 N/A N/A 41 4 No Early
ZM184F Unlinked C 11-Apr-03 10-Jul-03 45 71,290 72,718 N/A N/A 39 9 Yes Early
  1. Bolded subjects: superinfected individuals with evidence of superinfection from outsider partnerships or non-superinfected controls who self-reported outside partnerships.
  2. a Days from time of infection to first sample date was calculated, as follows: If only first Ab+ dates were available, time of infection was determined by the midpoint between last seronegative and first Ab+ date. If Ag+Ab- dates were available, time of infection was estimated by subtracting 22 days from Ag+Ab- dates. (Haaland 2009).
  3. b Viral load: RNA copies/ml in plasma at first sample date.
  4. c Viral load: RNA copies/ml in plasma at 7-12 months post-seroconversion.
  5. d Months post-seroconversion in which superinfection was detected, SI = Superinfection, N/A = Not Applicable.
  6. e Viral load: RNA copies/ml in plasma at time of superinfection detection.
  7. f Sexual data is cumulative events for 12 months (Kraft 2012).
  8. g Other partners self-reported for 12 months (Kraft 2012).
  9. h Denotes if initial virus envelope (Env) tested represents a transmitted/founder Env or an early founder-like Env isolated from first sample date.