Figure 4

Summary of neutralization titers to initial and superinfecting variants. Plasma neutralizing antibody IC50 titers to the transmitted founder virus Env were determined over the course of the first year of infection for three superinfected (ZM282M, ZM211F and ZM247F, bolded) and ten non-superinfected (non-SI) case-matched controls (A). Non-superinfected controls that had self-reported outside partnerships are also bolded. Similarly, IC50s to superinfecting variants were determined over the course of the first year of infection for all three superinfected cases (B). Values represent mean IC50 values from two independent experiments. Asterisks mark time in which superinfection was detected in the superinfected cases.