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Figure 2 | Retrovirology

Figure 2

From: Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy

Figure 2

Replication kinetics of WT and mutant RTs in the absence and presence of AZT and tenofovir disoproxil fumarate (Tenofovir-DF). In each case, histograms show the relative replication capacity (%), compared to the WT virus in the absence of drug, based on the slopes of p24 antigen production of each recombinant virus after infection of stimulated PBMCs. The significance of the difference between slopes was calculated using the GraphPrism v. 4 software and significant p values are represented above the bars. Statistical analyses were performed by using a Student t test.

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