Single mutations in the transmembrane envelope protein abrogate the immunosuppressive property of HIV-1

Retrovirology

Table 1 Frequency of mutations in the isu domain in proviruses from infected patients

250 HIV-1 sequences most closely related to the isu domain with the consensus sequence shown in Figure 1 were analyzed for mutations in each position. Numbers indicate the frequency of a substitution at a given position. “-“ indicates that more than one nucleotide substitution is required to change the amino acid, “0” indicates absence of corresponding mutations among the 250 analyzed sequences, * indicates substituted residues. The most conserved residues are given in bold. Please note that no mutations 1LA, 1QA, 4RA, 6LA, 9EA and 14DA as well as no 3AG and 7AG were found.

ISSN: 1742-4690