Table 1 HTLV-1 p30-interacting host proteins

Proteasome activator complex subunit

Cell cycle and protein degradation

21

54

Heat shock protein 90 beta

Protein folding

9

14

Heat shock protein 90 alpha

Protein folding

7

8.2

Methylosome subunit pICln

Methylosome component

5

37

Reticulocalbin-2

Calcium binding

5

20

Succinate dehydrogenase [ubiquinone] flavoprotein subunit

Electron transport

5

9.2

Elongation factor Tu

Translation

5

17

Clathrin heavy chain 1

Vesicular transport

5

5.4

Protein arginine N-methyltransferase 5

Methyltransferase activity

4

16

Cofilin-1

Cytoskeleton organization

4

27

Malate dehydrogenase

Citric acid cycle

4

14

Protein phosphatase 1 G

Phosphatase activity

4

11

Importin-5

Nuclear import

3

3

Ubiquitin

Post translation modification

3

17.4

14–3–3 protein zeta/delta

Signaling pathways

3

17

Complement component 1 Q subcomponent-binding protein

Immune response

3

25

L-lactate dehydrogenase A chain

Glycolysis

3

13

Methylosome protein 50

Methylosome component

2

7.6

NEFA-interacting nuclear protein NIP30

Unknown

2

9.8

Fatty acid synthase

Fatty acid metabolism

2

0.68

Transgelin-2

Predicted muscle development

2

15

Alpha-1-antiproteinase

Serine protease inhibitor

2

7.7

DNAJ homolog subfamily A member 1

Chaperon activity

2

13

Ubiquitin-conjugating enzyme E2 L3

Ubiquitination activity

2

24

F-box only protein 22

Ubiquitination activity

2

6.2

Phosphoglycerate mutase 1

Glycolysis

2

13

Peptidyl-prolyl cis-trans isomerase

Protein folding

2

11

60 S ribosomal protein L3

Component of ribosome

2

8.7

60 S ribosomal protein L8

Component of ribosome

2

16

Hydroxyacyl-coenzyme A dehydrogenase

Fatty acid metabolism

1

9.6

Nucleosome assembly protein 1-like 1

Predicted nucleosome assembly

1

7.4

Arginyl-tRNA synthetase

Arginine tRNA ligation

1

2

Glucose-6-phosphate isomerase

Glycolysis

1

2.7

Apoptosis-inducing factor 1

Apoptosis

1

1.8

Mesencephalic astrocyte-derived neurotrophic factor

Neuronal growth factor

1

6.1

Inorganic pyrophosphatase 2

Inorganic phosphatase activity

1

4.8

Tetratricopeptide repeat protein 4

Predicted binding activity

1

2.6

Myosin-9

Cytoskeletal organization

1

0.82

Heterogeneous nuclear ribonucleoprotein K

mRNA processing

1

2.6

14–3–3 protein epsilon

Signaling pathways

1

11

Profilin-1

Cytoskeletal organization

1

10

60 S ribosomal protein L30

Component of ribosome

1

10