Human Immunodeficiency Virus gag and protease: partners in resistance

Retrovirology

Table 2 All Gag mutations associated with PI exposure and/or resistance and maturation inhibitor resistance

Gag mutation	Associated with PI exposure		Associated with PI resistance	Associated with maturation inhibitor resistance
Gag mutation	in vivo	in vitro	Associated with PI resistance	Associated with maturation inhibitor resistance
MA
E12K		yes [59, 60]
G62R		yes [61]
L75R		yes [59, 60]
R76K	yes [62, 63]		yes [62]
Y79F	yes [62, 63]		yes [62]
T81A	yes [62, 63]		yes [62]
K112E		yes [64]
CS MA/CA
V128I/T/A/del	yes [56, 65, 66]	yes [64]	yes [64]
Y132F	yes [46, 67]
CA
M200I		yes [64]
H219Q/P		yes [59, 60, 64]
CS CA/p2
A360V	yes [46]
V362I		yes [68]		yes [69, 70]
L363M/F/C/N/Y		yes [61]		yes [69, 71–74]
S368C/N		yes [51, 54]		yes [69]
p2
Q369H	yes [54]			yes [72, 74]
V370A/M/del	yes [54]			yes [69, 70, 72, 74–76]
T371del	yes [77]			yes [72, 74, 76]
CS p2/NC
S373P/Q/T	yes [51, 54, 78]
A374P/S	yes [78]
T375N/S	yes [46, 78]
I376V	yes [46, 51]
G381S	yes [46]
NC
I389T	yes [77]
V390A/D		yes [59, 60]
I401T/V	yes [77]	yes [64]
R409K		yes [59–61, 64]
CS NC/p1
E428G	yes [66]
Q430R		yes [44]
A431V	yes [10, 45, 46, 51, 55, 57, 77–83]	yes [10, 44, 84, 85]	yes [13, 55, 81]
K436E/R	yes [10, 55, 82]	yes [10]	yes [10, 13, 55]
I437T/V	yes [10, 45, 46, 51, 55, 78, 82, 86]	yes [10, 61]	yes [10, 13, 55]
CS p1/p6-gag
L449F/P/V	yes [9, 45, 46, 55–57, 67, 77, 79, 80, 82, 86]	yes [44, 49, 85, 87]	yes [55]
S451T/G/R	yes [55, 66]
R452S/K	yes [55, 66, 79, 82]	yes [87]	yes [55]
P453A/L/T	yes [9, 55, 57, 77, 81, 82][67]	yes [84, 87]	yes [9, 55]
p6-gag
E468K		yes [59]
Q474L	yes [77]
A487S	yes [77]
P497L	yes [77]
p6-pol
V484G/I/P/S	yes [88]
CS TFP/p6pol
D437N	yes [56, 64]

ISSN: 1742-4690