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Table 1 Natural variation of Gag cleavage sites in subtype B isolates

From: Human Immunodeficiency Virus gag and protease: partners in resistance

   

MA

  

//

  

CA

     

HXB2 aa

V

S

Q

N

Y

//

P

I

V

Q

N

   

position

128

129

130

131

132

//

133

134

135

136

137

   

variability (%)

3.5

-

4.3

-

3.5

//

-

-

0.9

0.9

-

   
   

CA

  

//

  

p2

     

HXB2 aa

K

A

R

V

L

//

A

E

A

M

A

Q

V

T

position

359

360

361

362

363

//

364

365

366

367

368

369

370

371

variability (%)

0.2

0.2

1.8

11.5

1.2

//

-

-

-

-

1.2

4.1

24.8

16.4

   

p2

  

//

  

NC

     

HXB2 aa

S

A

T

I

M

//

M

Q

R

G

N

   

position

373

374

375

376

377

//

378

379

380

381

382

   

variability (%)

36.3

32.6

42.7

23.6

1.8

//

5.5

-

40.9

5.5

2.1

   
   

NC

  

//

  

p1

     

HXB2 aa

E

R

Q

A

N

//

F

L

G

K

I

   

position

428

429

430

431

432

//

433

434

435

436

437

   

variability (%)

2.3

3.5

-

0.5

-

//

-

0.1

-

6.3

5.5

   
   

p1

  

//

  

p6

     

HXB2 aa

R

P

G

N

F

//

L

Q

S

R

P

   

position

444

445

446

447

448

//

449

450

451

452

453

   

variability (%)

-

0.1

-

-

-

//

9.1

-

22.8

-

8.4

   
  1. Data describing the natural variation at individual codons in the five Gag cleavage sites were pooled and the frequency of polymorphisms as compared to the HXB2 reference sequence was calculated. Only data describing subtype B isolates were included in the analysis. Codons 369-371 in p2 are included because of their important role in CA/p2 maturation inhibitor susceptibility.A dash indicates 100% conservation.