Moloney murine leukemia virus glyco-gag facilitates xenotropic murine leukemia virus-related virus replication through human APOBEC3-independent mechanisms

Table 3 Comparing cell lines to infection with XMRV and MX viruses

Recipient cells	Virus	Trial 1	Trial 2	Trial 3	Trial 4	Ave ± Std		Ave
Recipient cells	Virus	IU/ml^*	IU/ml	IU/ml	IU/ml	IU/ml	Relative infectivity**	MX/XMRV
HeLa	XMRV	1.0 X 10⁵	8.8 X 10⁴	1.6 X 10⁵	8.0 X 10⁴	1.1 ± 0.38 X 10⁵	1 ± 0	36.0
	MX	4.3 X 10⁶	3.1 X 10⁶	4.5 X 10⁶	3.1 X 10⁶	3.8 ± 0.78 X 10⁶	36.0 ± 6.52	36.0
293	XMRV	5.9 X 10⁵	1.2 X 10⁶	1.4 X 10⁶		1.1 ± 0.42 X 10⁶	9.24 ± 3.64	3.89
	MX	3.5 X 10⁶	4.2 X 10⁶	4.2 X 10⁶		3.9 ± 0.38 X 10⁶	35.9 ± 11.1	3.89
HepG2	XMRV		8.7 X 10⁵	2.0 X 10⁶	9.6 X 10⁵	1.3 ± 0.63 X 10⁶	11.4 ± 1.28	2.95
	MX		2.0 X 10⁶	7.7 X 10⁶	2.5 X 10⁶	4.1 ± 3.2 X 10⁶	33.6 ± 12.4	2.95
NRK	XMRV	1.2 X 10⁵	2.9 X 10⁴			7.4 ± 6.3 X 10⁴	0.754 ± 0.593	14.5
	MX	1.2 X 10⁶	8.4 X 10⁵			1.0 ± 0.29 X 10⁶	10.9 ± 2.01	14.5
DU145	XMRV	8.4 X 10³	5.1 X 10³			6.7 ± 2.3 X 10³	0.0705 ± 0.0176	20.8
	MX	1.5 X 10⁵	1.2 X 10⁵			1.4 ± 0.21 X 10⁵	1.47 ± 0.0846

The several cell lines were infected with XMRV or MX viruses that were produced from the infected 293 T cells (293 T/XMRV and 293 T/MX). *The infectious units (IU) were measured from the number of infectious centers that was normalized by the amount of Capsid in viruses and IU per ml was shown. **The relative infectivity to HeLa cells infected with XMRV viruses was shown.

ISSN: 1742-4690