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Table 2 The mutations for putative glyco-gag did not influence anti-viral activity of hA3G in XMRV infection

From: Moloney murine leukemia virus glyco-gag facilitates xenotropic murine leukemia virus-related virus replication through human APOBEC3-independent mechanisms

Virus hA3G Trial 1 Trial 2 Ave ± Std
IU/ml* Relative infectivity** IU/ml Relative infectivity IU/ml Relative infectivity
VP62 - 1.7 X 104 1 1.4 X 104 1 1.5 X 104 ± 2.3 X 103 0.209 ± 0.029
  + 3.2 X 103 0.188 3.2 X 103 0.229 3.2 X 103 ± 3.3 X 101  
VP62Δgg0 - 8.4 X 103 1 1.2 X 104 1 1.0 X 104 ± 2.3 X 103 0.196 ± 0.058
  + 1.3 X 103 0.155 2.8 X 103 0.237 2.0 X 103 ± 1.1 X 103  
VP62Δgg1 - 1.2 X 103 1 3.4 X 103 1 2.3 X 103 ± 1.5 X 103 0.240 ± 0.014
  + 3.0 X 102 0.250 7.7 X 102 0.230 5.4 X 102 ± 3.3 X 102  
VP62Δgg2 - 1.8 X 104 1 9.1 X 103 1 1.3 X 104 ± 6.0 X 103 0.234 ± 0.010
  + 4.0 X 103 0.227 2.2 X 103 0.241 3.1 X 103 ± 1.3 X 103  
VP62Δgg3 - 1.1 X 104 1 8.2 X 103 1 9.5 X 103 ± 1.8 X 103 0.214 ± 0.068
  + 2.8 X 103 0.262 1.4 X 103 0.165 2.1 X 103 ± 1.0 X 103  
VP62Δgg4 - 2.2 X 104 1 1.3 X 104 1 1.7 X 104 ± 6.2 X 103 0.258 ± 0.049
  + 6.4 X 103 0.292 2.9 X 103 0.223 4.7 X 103 ± 2.5 X 103  
  1. The 293 T cells were transfected with the XMRV expressing plasmid pVP62 along with the hA3G-V5 or control (pcDNA3) plasmids. The viruses were gathered 2 days post-transfection and were used for infectivity assay with HeLa cells. *The infectious units (IU) were measured from the number of infectious centers that was normalized by the amount of Capsid in viruses and IU per ml was shown. **The relative infectivity to the HeLa cells infected with the viruses released from the 293 T cells transfected with control plasmid was shown.