Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal

Table 7 Pathological observations at time of euthanasia

Animal number	Most significant findings
29276	Chronic interstitial nephritis with tubular atrophy
	Hypophosphatemic osteomalacia
	Mild generalized lymphoid hyperplasia
30577	Lymphofollicular hyperplasia, mild (inguinal, axillary, tracheobronchial, and mesenteric lymph nodes; MALT (mucosa-associated lymphoid tissue) of cecum and stomach) to moderate (tonsil, spleen, ileocecocolic lymph nodes).
32186	Kidney: polycystic chronic interstitial nephritis with tubular atrophy
32186	Lymph nodes: mild paracortical hyperplasia and mild loss of germinal centers
33088	Mild multifocal hepatitis, mild colitis, mild tracheitis
33091	Heart: valvular vegetative endocarditis
	Bone marrow and ileum: moderate multifocal lymphoid hyperplasia
	Lymph nodes: mild to moderate paracortical hyperplasia with indistinct germinal centers
	Spleen: mild lymphoid depletion

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