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Table 5 Summary of plasma and PBMC-associated virus levels shortly before and after tenofovir withdrawal

From: Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal

 

30577

32186

33088

33091

Plasma

PBMC

Plasma

PBMC

Plasma

PBMC

Plasma

PBMC

Time after tenofovir withdrawal

RNA

DNA

RNA

RNA

DNA

RNA

RNA

DNA

RNA

RNA

DNA

RNA

- 24 wks

< 10

4

1

< 10

1

< 1

< 10

4

4

4,300

20

5

- 12 wks

< 15

7

2

< 10

< 1

< 1

< 15

3

< 1

38,000

20

20

- 4 wks

170

8

< 2

< 30

< 1

< 1

< 30

4

1

42,000

80

80

0

< 15

< 3

< 3

20

< 1

< 1

< 15

< 3

< 3

62,000

30

30

3 wks

780

< 2

< 2

20

< 3

< 3

< 15

< 3

< 3

120,000

60

50

4 wks

1,100

< 3

6

30

< 3

< 3

< 15

4

3

53,000

140

70

8 wks

< 30

7

2

< 30

1

2

< 30

3

8

41,000

50

130

12 wks

< 12

2

< 1

< 12

1

< 1

< 12

4

< 1

130,000

50

50

16 wks

120

8

< 1

20

4

< 1

< 12

7

< 1

70,000

90

20

24 wks

< 10

10

< 3

< 10

6

< 4

20

9

< 4

100,000

200

160

32 wks

350

4

< 1

< 10

3

< 1

< 10

5

2

170,000

150

270

36 wks

15

7

< 1

< 10

7

< 3

< 10

3

< 1

310,000

170

120

37 wks

< 10

5

< 1

3,600

9

< 4

< 10

2

< 1

460,000

160

110

39 wks

< 10

10

< 6

470

15

< 3

< 10

7

7

550,000

180

430

40 wks

20

4

< 1

320

7

< 4

< 10

2

< 1

650,000

180

290

41-43 wksa

< 10

7

< 2

20

15

< 1

< 10

6

< 1

530,000

280

470

  1. Cell-free levels in plasma are expressed as RNA copies per ml plasma. Cell-associated levels are expressed as number of viral RNA and DNA copies per 100,000 cell equivalents. Values are given relative to the time of permanent tenofovir withdrawal (=time zero). Results of samples from other time points that are not shown in these tables were used for the analysis of Table 3.
  2. aValues for 41–43 weeks after tenofovir withdrawal are those at the time of euthanasia.