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Table 5 Summary of plasma and PBMC-associated virus levels shortly before and after tenofovir withdrawal

From: Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal

  30577 32186 33088 33091
Plasma PBMC Plasma PBMC Plasma PBMC Plasma PBMC
Time after tenofovir withdrawal RNA DNA RNA RNA DNA RNA RNA DNA RNA RNA DNA RNA
- 24 wks < 10 4 1 < 10 1 < 1 < 10 4 4 4,300 20 5
- 12 wks < 15 7 2 < 10 < 1 < 1 < 15 3 < 1 38,000 20 20
- 4 wks 170 8 < 2 < 30 < 1 < 1 < 30 4 1 42,000 80 80
0 < 15 < 3 < 3 20 < 1 < 1 < 15 < 3 < 3 62,000 30 30
3 wks 780 < 2 < 2 20 < 3 < 3 < 15 < 3 < 3 120,000 60 50
4 wks 1,100 < 3 6 30 < 3 < 3 < 15 4 3 53,000 140 70
8 wks < 30 7 2 < 30 1 2 < 30 3 8 41,000 50 130
12 wks < 12 2 < 1 < 12 1 < 1 < 12 4 < 1 130,000 50 50
16 wks 120 8 < 1 20 4 < 1 < 12 7 < 1 70,000 90 20
24 wks < 10 10 < 3 < 10 6 < 4 20 9 < 4 100,000 200 160
32 wks 350 4 < 1 < 10 3 < 1 < 10 5 2 170,000 150 270
36 wks 15 7 < 1 < 10 7 < 3 < 10 3 < 1 310,000 170 120
37 wks < 10 5 < 1 3,600 9 < 4 < 10 2 < 1 460,000 160 110
39 wks < 10 10 < 6 470 15 < 3 < 10 7 7 550,000 180 430
40 wks 20 4 < 1 320 7 < 4 < 10 2 < 1 650,000 180 290
41-43 wksa < 10 7 < 2 20 15 < 1 < 10 6 < 1 530,000 280 470
  1. Cell-free levels in plasma are expressed as RNA copies per ml plasma. Cell-associated levels are expressed as number of viral RNA and DNA copies per 100,000 cell equivalents. Values are given relative to the time of permanent tenofovir withdrawal (=time zero). Results of samples from other time points that are not shown in these tables were used for the analysis of Table 3.
  2. aValues for 41–43 weeks after tenofovir withdrawal are those at the time of euthanasia.