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Table 4 Virus levels in blood and tissues at time of euthanasia

From: Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal

Animal number Plasma PBMC Spleen Ax LN Ing LN Mes LN Thymus Tonsil Jejunum Colon
RNA DNA RNA DNA RNA DNA RNA DNA RNA DNA RNA DNA RNA DNA RNA DNA RNA DNA RNA
29276 <15 4 <2 2 1 3 2 3 <2 <1 <1 NA NA NA NA NA NA NA NA
30577 < 10 7 <2 <3 <3 4 <1 4 <1 7 <2 <2 <2 3 <1 <2 <2 2 <2
32186 20 15 <1 5 <1 40 9 7 90 30 200 <70 160 300 13,500 60 7 10 50
33088 < 10 6 <1 2 <1 8 10 4 1 5 3 <2 <2 3 1 <2 <2 <4 <4
33091 530,000 280 470 370 5,700 320 13,000 340 11,000 520 10,000 <2 50 570 30,000 60 640 50 160
  1. Cell-free levels in plasma are expressed as RNA copies per ml plasma. Cell-associated levels are expressed as number of viral RNA and DNA copies per 100,000 cell equivalents (determined by total copy number of CCR5 divided by two). < indicates below limit of detection (based on the detection limit of 30 viral RNA or DNA copies per reaction and the cell equivalents for the particular sample).
  2. Ax LN = axillary lymph node, Ing LN = inguineal lymph node; Mes LN = mesenteric lymph node; NA = not available.