Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal

Table 4 Virus levels in blood and tissues at time of euthanasia

Animal number	Plasma	PBMC		Spleen		Ax LN		Ing LN		Mes LN		Thymus		Tonsil		Jejunum		Colon
Animal number	RNA	DNA	RNA	DNA	RNA	DNA	RNA	DNA	RNA	DNA	RNA	DNA	RNA	DNA	RNA	DNA	RNA	DNA	RNA
29276	<15	4	<2	2	1	3	2	3	<2	<1	<1	NA	NA	NA	NA	NA	NA	NA	NA
30577	< 10	7	<2	<3	<3	4	<1	4	<1	7	<2	<2	<2	3	<1	<2	<2	2	<2
32186	20	15	<1	5	<1	40	9	7	90	30	200	<70	160	300	13,500	60	7	10	50
33088	< 10	6	<1	2	<1	8	10	4	1	5	3	<2	<2	3	1	<2	<2	<4	<4
33091	530,000	280	470	370	5,700	320	13,000	340	11,000	520	10,000	<2	50	570	30,000	60	640	50	160

Cell-free levels in plasma are expressed as RNA copies per ml plasma. Cell-associated levels are expressed as number of viral RNA and DNA copies per 100,000 cell equivalents (determined by total copy number of CCR5 divided by two). < indicates below limit of detection (based on the detection limit of 30 viral RNA or DNA copies per reaction and the cell equivalents for the particular sample).
Ax LN = axillary lymph node, Ing LN = inguineal lymph node; Mes LN = mesenteric lymph node; NA = not available.

ISSN: 1742-4690