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Table 3 Analysis of viral blips in animals with low viremia during tenofovir treatment and after tenofovir withdrawal

From: Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal

  During tenofovir treatment After tenofovir withdrawal  
Animal numbera Time window (weeks of infection)b Number of time points for plasma viral RNA analysis Number of time points with plasma viral RNA ≥ 50 copies per ml Peak plasma virus copies per ml (time point) Time window (weeks of infection)b Number of time points for plasma viral RNA analysis Number of time points with plasma viral RNA ≥ 50 copies per ml Peak plasma virus copies per ml (time point) One-sided p value for frequency of viremia ≥ 50 copies/ml during versus after tenofovir treatment
29276c 598-736 16 0 NAc NAc NAc NAc NAc NAc
30577 299-552 39 12 270 (513 wks) 553-595 wks 40 7 1,100 (556 wks) p = 0.13
32186 316-457 39 4 300 (418 wks) 458 -498 wks 40 9 3,600 (494 wks) p = 0.13
33088 284-425 38 2 200 (386 wks) 426-468 wks 40 0 30 (435 wks) p = 0.23