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Table 3 Analysis of viral blips in animals with low viremia during tenofovir treatment and after tenofovir withdrawal

From: Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal

 

During tenofovir treatment

After tenofovir withdrawal

 

Animal numbera

Time window (weeks of infection)b

Number of time points for plasma viral RNA analysis

Number of time points with plasma viral RNA ≥ 50 copies per ml

Peak plasma virus copies per ml (time point)

Time window (weeks of infection)b

Number of time points for plasma viral RNA analysis

Number of time points with plasma viral RNA ≥ 50 copies per ml

Peak plasma virus copies per ml (time point)

One-sided p value for frequency of viremia ≥ 50 copies/ml during versus after tenofovir treatment

29276c

598-736

16

0

NAc

NAc

NAc

NAc

NAc

NAc

30577

299-552

39

12

270 (513 wks)

553-595 wks

40

7

1,100 (556 wks)

p = 0.13

32186

316-457

39

4

300 (418 wks)

458 -498 wks

40

9

3,600 (494 wks)

p = 0.13

33088

284-425

38

2

200 (386 wks)

426-468 wks

40

0

30 (435 wks)

p = 0.23