Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal

Table 2 Typing of MHC class I alleles of SIV-infected animals

Animal #	A01	A02	A08	A11	B01	B03	B04	B08	B17	MHC score^a
29276	-	-	-	-	-	-	-	-	-	0
32186	-	-	-	-	-	-	-	-	-	0
30577	+	-	-	+	-	-	-	-	-	+1
33088	-	-	-	-	+	-	-	+	-	0
33091	+	-	-	-	-	-	-	+	-	+2
CNPRC frequency (%)^b	18.8	13.8	13.0	9.1	29.9	1.2	1.5	7.1	11.2

^aThe MHC score was calculated by adding one point for each protective allele (Mamu-A*01, B*08, B*17) and subtracting a point for Mamu-B*01, which has been associated with higher viral levels; other alleles are given a zero score [18–21].
^bFrequency of alleles in the general rhesus macaque colony of the California National Primate Research Center; there was no statistically significant difference in frequency between the 5 SIV-infected animals and the general frequency for any of these alleles (p values > 0.5).

ISSN: 1742-4690