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Table 2 Typing of MHC class I alleles of SIV-infected animals

From: Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal

Animal # A01 A02 A08 A11 B01 B03 B04 B08 B17 MHC scorea
29276 - - - - - - - - - 0
32186 - - - - - - - - - 0
30577 + - - + - - - - - +1
33088 - - - - + - - + - 0
33091 + - - - - - - + - +2
CNPRC frequency
(%)b
18.8 13.8 13.0 9.1 29.9 1.2 1.5 7.1 11.2  
  1. aThe MHC score was calculated by adding one point for each protective allele (Mamu-A*01, B*08, B*17) and subtracting a point for Mamu-B*01, which has been associated with higher viral levels; other alleles are given a zero score [1821].
  2. bFrequency of alleles in the general rhesus macaque colony of the California National Primate Research Center; there was no statistically significant difference in frequency between the 5 SIV-infected animals and the general frequency for any of these alleles (p values > 0.5).