Figure 4From: Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawalT cell apoptosis and exhaustion phenotype in SIV-infected rhesus macaques after tenofovir withdrawal and uninfected macaques. CD3 + 4+ T cells (A, C) and CD3 + 8+ T cells (B, D) from PBMC and tissue lymphoid cells were assessed via multiparameter flow cytometry for apoptotic cells, Caspase3 + Bcl2-, (A, B) and exhausted cells, PD-1 + Bcl2- (C, D). Data are reported as the frequency of the aforementioned cell populations in the CD4 + CD3+ or CD3 + CD8+ T cell populations, and are compared to those of 3 uninfected animals. Animal 33091 is represented as a red square in all graphs.Back to article page