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Figure 4 | Retrovirology

Figure 4

From: Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal

Figure 4

T cell apoptosis and exhaustion phenotype in SIV-infected rhesus macaques after tenofovir withdrawal and uninfected macaques. CD3 + 4+ T cells (A, C) and CD3 + 8+ T cells (B, D) from PBMC and tissue lymphoid cells were assessed via multiparameter flow cytometry for apoptotic cells, Caspase3 + Bcl2-, (A, B) and exhausted cells, PD-1 + Bcl2- (C, D). Data are reported as the frequency of the aforementioned cell populations in the CD4 + CD3+ or CD3 + CD8+ T cell populations, and are compared to those of 3 uninfected animals. Animal 33091 is represented as a red square in all graphs.

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