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Table 6 Detection of virus following challenge with heterologous SHIV SF33 (50 MID50 dose)

From: Heterologous protection elicited by candidate monomeric recombinant HIV-1 gp120 vaccine in the absence of cross neutralising antibodies in a macaque model

GROUP

ID NO.

VACCINE

OUTCOME OF CHALLENGE(Weeks Post Challenge)

   

−4

2

4

8

12

20

   

VI

PCR

VI

VI

PCR

VI

PCR

VI

B

A72

30 μg W61D rgp120/AS02A i.m

-

+

+

ND

+

-

+

-

 

A73

 

-

+

+

ND

+

-

+

-

 

A74

 

-

-

+

ND

-

+

+

-

 

A77

 

-

+

+

ND

+

+

+

-

D

B238

AS02A i.m

-

+

+

-

+

-

+

-

 

B239

         
 

B240

 

-

+

+

-

+

-

+

-

 

B241

 

-

-

+

-

+

-

+

-

   

-

+

+

-

-

+

+

-

  1. VI = Virus isolation by co-culture of 5 x 106 PBMC with 105 C8166 indicator cells.
  2. PCR = Diagnostic DNA PCR specific for SIV gag.
  3. ND = Assay not performed.