Skip to main content

Table 6 Detection of virus following challenge with heterologous SHIV SF33 (50 MID50 dose)

From: Heterologous protection elicited by candidate monomeric recombinant HIV-1 gp120 vaccine in the absence of cross neutralising antibodies in a macaque model

GROUP ID NO. VACCINE OUTCOME OF CHALLENGE(Weeks Post Challenge)
    −4 2 4 8 12 20
    VI PCR VI VI PCR VI PCR VI
B A72 30 μg W61D rgp120/AS02A i.m - + + ND + - + -
  A73   - + + ND + - + -
  A74   - - + ND - + + -
  A77   - + + ND + + + -
D B238 AS02A i.m - + + - + - + -
  B239          
  B240   - + + - + - + -
  B241   - - + - + - + -
    - + + - - + + -
  1. VI = Virus isolation by co-culture of 5 x 106 PBMC with 105 C8166 indicator cells.
  2. PCR = Diagnostic DNA PCR specific for SIV gag.
  3. ND = Assay not performed.