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Table 5 Detection of virus following transfer of immune serum from W61D rgp120 immunised macaques and challenge with SHIV sbg (50 MID50 dose)

From: Heterologous protection elicited by candidate monomeric recombinant HIV-1 gp120 vaccine in the absence of cross neutralising antibodies in a macaque model

GROUP ID NUMBER TREATMENT OUTCOME OF CHALLENGE (Weeks Post Challenge)
    −2   2   4 9 10 20
    VI VI VT* PCR PCR VI VI VI
E C37 50 ml pooled serum from A71, A75, A76, A78 i.p day −1 - + 2.5 - + + ND -
  C38   - + 2.0 + + + ND +
  C39   - + 2.0 + + + ND -
  C40   - + 1.5 + + + ND -
F C41 None - ND 2.5 + + ND - -
  C42   - ND 1.0 - + ND - -
  C43   - ND 3.0 + + ND - -
  C44   - ND 3.0 + + ND + -
  1. VT* = Virus Titration; Number of SIV + ve cells per 106 PBMC.
  2. VI = Virus isolation by co-culture of 5 x 106 PBMC with 105 C8166 indicator cells.
  3. PCR = Diagnostic DNA PCR specific for SIV gag.
  4. ND = Assay not performed.