Skip to main content

Table 3 Detection of virus following challenge with heterologous SHIV sbg (10 MID50 dose)

From: Heterologous protection elicited by candidate monomeric recombinant HIV-1 gp120 vaccine in the absence of cross neutralising antibodies in a macaque model

GROUP ID NO. VACCINE OUTCOME OF CHALLENGE(Weeks Post Challenge)
    −4 2 4 8 12 16 20
    VI VT* PCR VI PCR PCR VI PCR VI
A A71 30 μg W61D rgp120/AS02A i.m - <0.5 - - - - - - -
  A75   - <0.5 - - - - - - -
  A76   - <0.5 - - - - - - -
  A78   - <0.5 - - - - - - -
C B234 AS02A i.m - <0.5 - - - - - - -
  B235   - 1.5 + + + + - - -
  B236   - 3.0 + + + + - + -
  B237   - 3.0 + + + + + - -
  1. VT* = Virus Titration; Number of SIV + ve cells per 106 PBMC.
  2. VI = Virus isolation by co-culture of 5 x 106 PBMC with 105 C8166 indicator cells.
  3. PCR = Diagnostic DNA PCR specific for SIV gag.