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Table 3 Detection of virus following challenge with heterologous SHIV sbg (10 MID50 dose)

From: Heterologous protection elicited by candidate monomeric recombinant HIV-1 gp120 vaccine in the absence of cross neutralising antibodies in a macaque model

GROUP

ID NO.

VACCINE

OUTCOME OF CHALLENGE(Weeks Post Challenge)

   

−4

2

4

8

12

16

20

   

VI

VT*

PCR

VI

PCR

PCR

VI

PCR

VI

A

A71

30 μg W61D rgp120/AS02A i.m

-

<0.5

-

-

-

-

-

-

-

 

A75

 

-

<0.5

-

-

-

-

-

-

-

 

A76

 

-

<0.5

-

-

-

-

-

-

-

 

A78

 

-

<0.5

-

-

-

-

-

-

-

C

B234

AS02A i.m

-

<0.5

-

-

-

-

-

-

-

 

B235

 

-

1.5

+

+

+

+

-

-

-

 

B236

 

-

3.0

+

+

+

+

-

+

-

 

B237

 

-

3.0

+

+

+

+

+

-

-

  1. VT* = Virus Titration; Number of SIV + ve cells per 106 PBMC.
  2. VI = Virus isolation by co-culture of 5 x 106 PBMC with 105 C8166 indicator cells.
  3. PCR = Diagnostic DNA PCR specific for SIV gag.
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Retrovirology

ISSN: 1742-4690

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