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Table 2 Serological responses following immunisation with HIV-1 W61D rgp120

From: Heterologous protection elicited by candidate monomeric recombinant HIV-1 gp120 vaccine in the absence of cross neutralising antibodies in a macaque model

GROUP

ID NO.

VACCINE

SEROLOGICAL RESPONSES

   

Binding Antibodies(log10 reciprocal titre)

Virus Neutralisation Activity(50% virus inhibition log10 titre)

   

W61D rgp120 week 50a

IIIB rgp120 DOCa

SHIVW61DDOCa

SHIVW61D

week 50a

SHIVsbgDOCa

SHIV-4 DOCa

SHIVSF33week 50a

SHIVSF33week140a

A

A71

30μg W61D rgp120/AS02A i.m

3.9

3.5

2.9

 

<1

1.6

  
 

A75

 

3.9

3.7

3.1

 

<1

1.5

  
 

A76

 

4.2

3.8

3.1

 

<1

1.2

  
 

A78

 

4.1

3.5

3.2

 

<1

1.4

  

C

B234

AS02A i.m

    

<1

   
 

B235

     

<1

   
 

B236

     

<1

   
 

B237

     

<1

   

B

A72

30μg W61D rgp120/AS02A i.m

4.0

  

2.7

 

1.5

1.5

 
 

A73

 

3.9

  

2.7

 

1.4

1.4

 
 

A74

 

4.0

  

2.7

 

1.5

1.5

 
 

A77

 

4.3

  

2.3

 

1.6

1.6

 

D

B238

AS02A i.m

       

2.4

 

B239

        

>2.7

 

B240

        

2.2

 

B241

        

>3.4

  1. DOC = day of challenge.
  2. a = time of sampling.