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Table 3 Logistic Regression for predicting transmission based on number of conserved glycosites

From: Application of a case–control study design to investigate genotypic signatures of HIV-1 transmission

 

Univariate Odd Ratio (95% confidence interval)

p-value

 

Odds Ratio with subtype interaction (95% confidence interval)

p-value

Test for Homogeneity between subtype, p-value

Wilcoxon Rank-Sum, p-value

PNGs in C1

 

PNGs in C1

    

0 to 1

  

Subtype B  0 to 1

   

0.538

2

  

2

0.78 (0.34, 1.74)

0.538

  
   

Subtype  C 0 to 1

   

0.661

   

2

2.63 (0.20, 34.07)

0.46

0.45

 

PNGs in C2

 

PNGs in C2

    

0

  

Subtype B  0

   

1

1

0.66 (0.18, 2.38)

0.522

1

1.0 (0.14, 7.28)

1

  
   

Subtype C  0

   

0.403

   

1

0.48 (0.03, 6.74)

0.587

0.587

 

PNGs in C3

  

PNGs in C3

    

0 to 5

  

Subtype B  0 to 5

0.81 (0.29, 2.24)

0.68

 

0.669

6

0.76 (0.34, 1.72)

0.51

6

1.36 (0.50, 3.70)

0.551

  

7

0.79 (0.36, 1.73)

0.558

7

0.56 (0.14, 2.26)

0.411

  

8

0.58 (0.21, 1.62)

0.302

8

    
   

Subtype C  0 to 5

   

0.142

   

6

0.86 (0.15, 4.85)

0.863

  
   

7

0.26 (0.05, 1.37)

0.113

  
   

8

0.90 (0.11, 7.51)

0.922

0.214

 

PNGs in C4

  

PNGs in C4

    

0 to 3

  

Subtype B  0 to 3

   

0.772

4

0.93 (0.51, 1.71)

0.818

4

1.03 (0.41, 2.58)

0.952

  

5

079 (0.43, 1.46)

0.446

5

1.13 (0.48, 2.65)

0.782

  
   

Subtype C  0 to 3

   

0.148

   

4

0.87 (0.25, 2.96)

0.818

  
   

5

0.23 (0.05, 1.09)

0.064

0.107

 

PNGs in C5

 

PNGs in C5

    

0

  

Subtype  B 0

   

0.518

1

1.02 (0.25, 4.23)

0.974

1

0.49 (0.09, 2.78)

0.423

  

2

0.96 (0.22, 4.06)

0.951

2

0.44 (0.06, 3.16)

0.413

  
   

Subtype C  0

   

0.951

   

1

    
   

2

  

0.532

 
  1. Note: In groups where no sequences have 0 glycosites, logistic regression cannot be performed.