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Figure 6 | Retrovirology

Figure 6

From: Identification of novel subgroup A variants with enhanced receptor binding and replicative capacity in primary isolates of anaemogenic strains of feline leukaemia virus

Figure 6

The DD mutation confers enhanced binding of Fc-SU to multiple receptors. Matched volumes of supernatant containing the Fc-SU fusion proteins from Glasgow-1 (A), Gardner-Arnstein (B), Sarma (C), or the mutants DD, ND and NN, were added to either MDTF or 104 C1 cells expressing feline, human or porcine THTR1, human FLVCR1 & 2, human Pit1 (MDTF only), or vector only (CON). Fc-SU binding was detected by flow cytometry with PE-conjugated anti-human IgG-Fc. Each histogram represents 10,000 events collected in LIST mode and are representative of two independent analyses. Ordinate displays number of events while abscissa displays fluorescence intensity.

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Retrovirology

ISSN: 1742-4690

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