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Figure 4 | Retrovirology

Figure 4

From: HTLV-1 modulates the frequency and phenotype of FoxP3+CD4+T cells in virus-infected individuals

Figure 4

Characterization of FoxP3+CD4+T-cell subset in AC samples. (A) A result of flow cytometric dot plots of CD45RA and FoxP3 in CD4+ T cells of an AC sample is shown as an example. FoxP3+CD4+ T cells were classified into three subsets. a, CD45RA+FoxP3low resting Treg cells (rTreg cells); b, CD45RA−FoxP3low non-regulatory T cells (FoxP3low non-Treg cells), c, CD45RA−FoxP3high activated Treg cells (aTreg cells). (B–D) Frequencies of the FoxP3+CD4+ T-cell subset in HD, AClow, and AChigh. Percentages of resting Treg cells (B), activated Treg cells (C), and FoxP3low non-Treg cells (D) in CD4+ T cells are shown. (E) Representative flow cytometric dot plots of CD45RA and FoxP3 and histograms of Tax expression in each CD4+ T-cell subset in an AC sample (Left panel). Cumulative results from 13 AClow and 10 AChigh individuals are shown in the graph (Middle and right panels).

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