Figure 6

Distinct phenotypes in BLT humanized mice during long term infection with a high dose of LAINef dd. (A-B) Each line depicts longitudinal plasma viral load data (A), or the CD4⁺ T cell percentages (B) from individual BLT humanized mice infected with 600,000 TCIU of LAINefdd where each animal in (A) and (B) is symbol matched. Persistent viral replication and loss of CD4⁺ T cells in the peripheral blood were observed in each of these mice. (C-D) Each line depicts longitudinal plasma viral load data (C) or the CD4⁺ T cell percentages (D) from individual BLT humanized mice infected with 600,000 TCIU of LAINefdd where each animal in (C) and (D) is symbol matched. Viral replication and minimal loss of CD4⁺ T cells in the blood were observed in these mice over this extended experimental analysis.